Potent Antibacterial Peptides Generated by Pepsin Digestion of Bovine Lactoferrin
نویسندگان
چکیده
منابع مشابه
Antibacterial activity in bovine lactoferrin-derived peptides.
Several peptides sharing high sequence homology with lactoferricin B (Lf-cin B) were generated from bovine lactoferrin (Lf) with recombinant chymosin. Two peptides were copurified, one identical to Lf-cin B and another differing from Lf-cin B by the inclusion of a C-terminal alanine (lactoferricin). Two other peptides were copurified from chymosin-hydrolyzed Lf, one differing from Lf-cin B by t...
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Although the antimicrobial activity of lactoferrin has been well described, its mechanism of action has been poorly characterized. Recent work has indicated that in addition to binding iron, human lactoferrin damages the outer membrane of gram-negative bacteria. In this study, we determined whether bovine lactoferrin and a pepsin-derived bovine lactoferrin peptide (lactoferricin) fragment have ...
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ژورنال
عنوان ژورنال: Journal of Dairy Science
سال: 1991
ISSN: 0022-0302
DOI: 10.3168/jds.s0022-0302(91)78608-6